Nanotemplated polyelectrolyte films as porous biomolecular delivery systems. Application to the growth factor BMP-2.

Nanotemplated polyelectrolyte films as porous biomolecular delivery systems

Tissue integration of growth factor-eluting layer-by-layer polyelectrolyte multilayer coated implants.

Drug eluting coatings that can direct the host tissue response to implanted medical devices have the potential to ameliorate both the medical and financial burden of complications from implantation. However, because many drugs useful in this arena are biologic in nature, a paucity of delivery strategies for biologics, including growth factors, currently limits the control that can be exerted on...

Secondary structure of rhBMP-2 in a protective biopolymeric carrier material.

Efficient delivery of growth factors is one of the great challenges of tissue engineering. Polyelectrolyte multilayer films (PEM) made of biopolymers have recently emerged as an interesting carrier for delivering recombinant human bone morphogenetic protein 2 (rhBMP-2 noted here BMP-2) to cells in a matrix-bound manner. We recently showed that PEM made of poly(l-lysine) and hyaluronan (PLL/HA) ...

Fabrication and Characterization of Chitosan/Alginate Multilayer Composite Membrane Supported by a Porous Poly (Acrylonitrile) Substrate for Pervaporation Dehydration of Alcohol

Chitosan (CS) and alginate (Alg) are complementary in their membrane performance, but the combination of them is normally difcult to use due to their different solubilities. Layer-by-Layer deposition appears to be an effective method for improving the separation efciency of a composite membrane. In this work, the polyelectrolyte multilayer composite membranes (PEMCMs) wer...

Enhanced bone regeneration of cortical segmental bone defects using porous titanium scaffolds incorporated with colloidal gelatin gels for time- and dose-controlled delivery of dual growth factors.

Porous titanium scaffolds are a promising class of biomaterials for grafting large bone defects, because titanium provides sufficient mechanical support, whereas its porous structure allows bone ingrowth resulting in good osseointegration. To reinforce porous titanium scaffolds with biological cues that enhance and continue bone regeneration, scaffolds can be incorporated with bioactive gels fo...